Yan, Hui Zhu, Kongfu Teng, Maikun Li, Xu Dataset for: A newly identified photolyase from Arthrospira platensis possesses a unique MTHF binding model Cyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to disastrous diseases. Here, we identified a photolyase from Arthrospira platensis (designated as Ap-phr), which has been regarded as safe organism for humans for centuries. Ap-phr can efficiently repair CPD lesions in ssDNA and dsDNA in vitro, and the 1.6 Å resolution crystal structure of Ap-phr revealed that it possesses a unique MTHF-binding pattern with high energy transfer efficiency. Our study of Ap-phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications. Photolyase;Ap-phr;crystal structure;MTHF-binding;enzyme activity;Biophysics;Synthetic Biology;Biochemistry;Plant Biology;Virology;Cell Development, Proliferation and Death;Computational Biology;Immunology;Neuroscience;Receptors and Membrane Biology;Molecular Biology;Evolutionary Biology;Signal Transduction;Cancer Cell Biology;Systems Biology;Structural Biology 2019-11-01
    https://wiley.figshare.com/articles/dataset/Dataset_for_A_newly_identified_photolyase_from_Arthrospira_platensis_possesses_a_unique_MTHF_binding_model/10101407
10.6084/m9.figshare.10101407.v1