%0 Generic %A Jensen, Aksel %A Ravn, Henrik %A Sørup, Signe %A Andersen, Per %D 2016 %T Data From: A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations %U https://wiley.figshare.com/articles/dataset/Data_From_A_marginal_structural_model_for_recurrent_events_in_the_presence_of_time-dependent_confounding_non-specific_effects_of_vaccines_on_child_hospitalisations/3472757 %R 10.6084/m9.figshare.3472757.v1 %2 https://wiley.figshare.com/ndownloader/files/5467865 %K marginal structural model %K recurrent events %K continuously updated weights %K non-specific effects of vaccination %K multi-state model %K Medicine %K Statistics %X Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload. %I Wiley