Dataset for: RNA editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA Aparna Anantharaman Omid Gholamalamdari Abid Khan Je-Hyun Yoon Michael Jantsch Jochen C Hartner Myriam Gorospe Supriya G. Prasanth KV Prasanth 10.6084/m9.figshare.5306737.v1 https://wiley.figshare.com/articles/dataset/Dataset_for_RNA_editing_enzymes_ADAR1_and_ADAR2_coordinately_regulate_the_editing_and_expression_of_Ctn_RNA/5306737 Adenosine Deaminases acting on RNA (ADARs) are proteins that catalyze widespread A-to-I editing within RNA sequences. We recently reported that ADAR2 edits and stabilizes nuclear-retained Cat2 transcribed nuclear RNA (Ctn RNA). Here, we report that ADAR1 coordinates with ADAR2 to regulate editing and stability of Ctn RNA. We observe an RNA-dependent interaction between ADAR1 and ADAR2. Furthermore, ADAR1 negatively regulates interaction of Ctn RNA with RNA-destabilizing proteins. We also show that breast cancer (BC) cells display elevated ADAR1 but not ADAR2 levels, compared to non-tumorigenic cells. Additionally, BC patients with elevated levels of ADAR1 show low survival. Our findings provide insights into overlapping substrate preferences of ADARs and potential involvement of ADAR1 in breast cancer. 2017-08-30 13:17:00 ADAR; Ctn RNA; RNA editing; mRNA stability; breast cancer; HuR Biophysics Synthetic Biology Biochemistry Plant Biology Virology Receptors and Membrane Biology Computational Biology Immunology Neuroscience Cell Development, Proliferation and Death Molecular Biology Evolutionary Biology Signal Transduction Cancer Cell Biology Systems Biology Structural Biology