Dataset for: Model discrimination for Ca<sup>2+</sup>-dependent regulation of myosin light chain kinase in smooth muscle contraction
Joseph P. Dexter
John W. Biddle
Jeremy Gunawardena
10.6084/m9.figshare.6871136.v1
https://wiley.figshare.com/articles/dataset/Dataset_for_Model_discrimination_for_Ca_sup_2_sup_-dependent_regulation_of_myosin_light_chain_kinase_in_smooth_muscle_contraction/6871136
Excitation-contraction coupling in smooth muscle is mediated by the Ca<sup>2+</sup>- and calmodulin-dependent regulation of myosin light chain kinase. The precise mechanism of this regulation remains controversial, and several mathematical models have been proposed for the interaction of the three species. These models have previously been analyzed at steady state primarily by numerical simulation of differential equations, for which parameter values must be estimated from data. Here, we use the linear framework for timescale separation to demonstrate that models of this general kind can be solved analytically for an equilibrium steady state, without having to determine parameter values. This analysis leads to parameter-independent methods for discriminating between the models, for which we propose experiments that could be performed with existing methods.
2018-09-06 11:33:10
calcium signaling
linear framework
mathematical modeling
Biophysics
Synthetic Biology
Biochemistry
Plant Biology
Virology
Receptors and Membrane Biology
Computational Biology
Immunology
Neuroscience
Cell Development, Proliferation and Death
Molecular Biology
Evolutionary Biology
Signal Transduction
Cancer Cell Biology
Systems Biology
Structural Biology