%0 Generic %A Jeon, Bu-Nam %A Song, Ji-Yang %A Huh, Jin Won %A Yang, Woo-Ick %A Hur, Man-Wook %D 2019 %T Dataset for: Derepression of Mmp gene transcription and an emphysema-like phenotype in Zbtb7c knockout mouse lungs %U https://wiley.figshare.com/articles/dataset/Dataset_for_Derepression_of_Mmp_gene_transcription_and_an_emphysema-like_phenotype_in_Zbtb7c_knockout_mouse_lungs/8279699 %R 10.6084/m9.figshare.8279699.v1 %2 https://wiley.figshare.com/ndownloader/files/15480056 %K Emphysema %K MMP (matrix metalloproteinases) %K Zbtb7c (Kr-pok) %K Cigarette smoking %K Biophysics %K Synthetic Biology %K Biochemistry %K Plant Biology %K Virology %K Cell Development, Proliferation and Death %K Computational Biology %K Immunology %K Neuroscience %K Receptors and Membrane Biology %K Molecular Biology %K Evolutionary Biology %K Signal Transduction %K Cancer Cell Biology %K Systems Biology %K Structural Biology %X Dysregulated MMP expression is a major cause of the degradation of lung tissue that is integral to emphysema pathogenesis. Cigarette smoking (CS) increases MMP gene expression, a major contributor to emphysema development. We previously reported that Zbtb7c is a transcriptional repressor of several Mmp genes (Mmps-8, -10, -13, and -16). Here, we show that Zbtb7c knockout mice have mild emphysema-like phenotypes, including alveolar wall destruction, enlarged alveoli, and upregulated Mmp genes. Alveolar size and Mmp gene expression, in Zbtb7c-/- mouse lungs, were increased more severely upon exposure to CS, compared to those of Zbtb7c+/+ mouse lungs. These observations suggest that Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema. %I Wiley