Jeon, Bu-Nam Song, Ji-Yang Huh, Jin Won Yang, Woo-Ick Hur, Man-Wook Dataset for: Derepression of Mmp gene transcription and an emphysema-like phenotype in Zbtb7c knockout mouse lungs Dysregulated MMP expression is a major cause of the degradation of lung tissue that is integral to emphysema pathogenesis. Cigarette smoking (CS) increases MMP gene expression, a major contributor to emphysema development. We previously reported that Zbtb7c is a transcriptional repressor of several Mmp genes (Mmps-8, -10, -13, and -16). Here, we show that Zbtb7c knockout mice have mild emphysema-like phenotypes, including alveolar wall destruction, enlarged alveoli, and upregulated Mmp genes. Alveolar size and Mmp gene expression, in Zbtb7c-/- mouse lungs, were increased more severely upon exposure to CS, compared to those of Zbtb7c+/+ mouse lungs. These observations suggest that Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema. Emphysema;MMP (matrix metalloproteinases);Zbtb7c (Kr-pok);Cigarette smoking;Biophysics;Synthetic Biology;Biochemistry;Plant Biology;Virology;Cell Development, Proliferation and Death;Computational Biology;Immunology;Neuroscience;Receptors and Membrane Biology;Molecular Biology;Evolutionary Biology;Signal Transduction;Cancer Cell Biology;Systems Biology;Structural Biology 2019-07-31
    https://wiley.figshare.com/articles/dataset/Dataset_for_Derepression_of_Mmp_gene_transcription_and_an_emphysema-like_phenotype_in_Zbtb7c_knockout_mouse_lungs/8279699
10.6084/m9.figshare.8279699.v1