Data from: Parallel NMR Spectroscopy With Simultaneous Detection of 1H and 19F Nuclei

2016-05-05T08:27:45Z (GMT) by Helena Kovacs Eriks Kupce
NMR instruments equipped with multiple receivers can significantly increase the information content in experiments by recording multiple free induction decays (FID-s) from several nuclear species in a single pass. This in turn reduces the number of experiments required to solve a particular analytical or structure elucidation problem. We present a comprehensive series of such experiments that involve multi-receiver detection of two of the most sensitive NMR nuclei – 1H and 19F. The experiment designs are categorized into three main groups – (i) interleaved experiments, (ii) parallel acquisition experiments and (iii) sequential acquisition experiments. The interleaved experiments are based on independent pulse programs that are typically dealing with more or less isolated spin systems and avoid perturbing spin system(s) that are recovering while the experiment involving the active spin system is conducted. The parallel acquisition experiments are based on simultaneous observation of the free induction decays (FID-s) of several spin systems in parallel. The multi-dimensional experiments of this type usually involve joint coherence transfer pathways and one or more joint frequency domains. Finally, the sequential acquisition experiments involve direct observation of one or more FID-s within the pulse sequence and otherwise are similar to the parallel acquisition experiments. Several examples of each type of multi-receive H/F experiments involving the most popular NMR pulse sequences including COSY, TOCSY, DOSY, HOESY, HETCOR, HSQC, HMQC, HMBC and T1 measurement by inversion recovery method are presented and discussed. Furthermore, we demonstrate that efficiency of such experiments can be further improved by combining the multi-receiver methodology with the modern approaches of fast methods, such as relaxation optimization, non-uniform sampling, Hadamard encoding, computer-optimized folding and ultra-fast NMR by spatial encoding. We believe that the multi-receiver technology is set to become a routine way of multiplying the efficiency and throughput in high-resolution NMR spectroscopy.