Dataset for: A newly identified photolyase from Arthrospira platensis possesses a unique MTHF binding model

Cyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to disastrous diseases. Here, we identified a photolyase from Arthrospira platensis (designated as Ap-phr), which has been regarded as safe organism for humans for centuries. Ap-phr can efficiently repair CPD lesions in ssDNA and dsDNA in vitro, and the 1.6 Å resolution crystal structure of Ap-phr revealed that it possesses a unique MTHF-binding pattern with high energy transfer efficiency. Our study of Ap-phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications.