validation report.pdf (1.17 MB)
Dataset for: A newly identified photolyase from Arthrospira platensis possesses a unique MTHF binding model
dataset
posted on 2019-11-01, 20:55 authored by Hui Yan, Kongfu Zhu, Maikun Teng, Xu LiCyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to disastrous diseases. Here, we identified a photolyase from Arthrospira platensis (designated as Ap-phr), which has been regarded as safe organism for humans for centuries. Ap-phr can efficiently repair CPD lesions in ssDNA and dsDNA in vitro, and the 1.6 Å resolution crystal structure of Ap-phr revealed that it possesses a unique MTHF-binding pattern with high energy transfer efficiency. Our study of Ap-phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications.
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Categories
- Animal physiology - biophysics
- Human biophysics
- Synthetic biology
- Biochemistry and cell biology not elsewhere classified
- Plant biology not elsewhere classified
- Virology
- Cell development, proliferation and death
- Bioinformatics and computational biology not elsewhere classified
- Immunology not elsewhere classified
- Neurosciences not elsewhere classified
- Receptors and membrane biology
- Plant cell and molecular biology
- Animal cell and molecular biology
- Evolutionary biology not elsewhere classified
- Signal transduction
- Cancer cell biology
- Systems biology
- Structural biology (incl. macromolecular modelling)
Keywords
PhotolyaseAp-phrcrystal structureMTHF-bindingenzyme activityBiophysicsSynthetic BiologyBiochemistryPlant BiologyVirologyCell Development, Proliferation and DeathComputational BiologyImmunologyNeuroscienceReceptors and Membrane BiologyMolecular BiologyEvolutionary BiologySignal TransductionCancer Cell BiologySystems BiologyStructural Biology
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