Dataset for: Controlled pattern imputation for sensitivity analysis of longitudinal binary and ordinal outcomes with nonignorable dropout

2018-01-15T05:57:01Z (GMT) by Yongqiang Tang
The controlled imputation method refers to a class of pattern mixture models (PMM) that have been commonly used as sensitivity analyses of longitudinal clinical trials with nonignorable dropout in recent years. These PMMs assume that subjects in the experimental arm after dropout have similar response profiles to the control subjects, or have worse outcomes than otherwise similar subjects who remain on the experimental treatment. In spite of its popularity, the controlled imputation has not been formally developed for longitudinal binary and ordinal outcomes partially due to the lack of a natural multivariate distribution for such endpoints. In this paper, we propose two approaches for implementing the controlled imputation for binary and ordinal data based respectively on the sequential logistic regression and the multivariate probit model. Efficient Markov chain Monte Carlo algorithms are developed for missing data imputation by using the monotone data augmentation (MDA) technique for the sequential logistic regression, and a parameter expanded MDA scheme for the multivariate probit model.We assess the performance of the proposed procedures by simulation and the analysis of a schizophrenia clinical trial, and compare them with the fully conditional specification, last observation carried forward, and baseline observation carried forward imputation methods.