(marked) FEBSL-19-0221.R2.docx (153.33 kB)
Dataset for: Derepression of Mmp gene transcription and an emphysema-like phenotype in Zbtb7c knockout mouse lungs
dataset
posted on 2019-07-31, 15:17 authored by Bu-Nam Jeon, Ji-Yang Song, Jin Won Huh, Woo-Ick Yang, Man-Wook HurDysregulated MMP expression is a major cause of the degradation of lung tissue that is integral to emphysema pathogenesis. Cigarette smoking (CS) increases MMP gene expression, a major contributor to emphysema development. We previously reported that Zbtb7c is a transcriptional repressor of several Mmp genes (Mmps-8, -10, -13, and -16). Here, we show that Zbtb7c knockout mice have mild emphysema-like phenotypes, including alveolar wall destruction, enlarged alveoli, and upregulated Mmp genes. Alveolar size and Mmp gene expression, in Zbtb7c-/- mouse lungs, were increased more severely upon exposure to CS, compared to those of Zbtb7c+/+ mouse lungs. These observations suggest that Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema.
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Categories
- Animal physiology - biophysics
- Human biophysics
- Synthetic biology
- Biochemistry and cell biology not elsewhere classified
- Plant biology not elsewhere classified
- Virology
- Cell development, proliferation and death
- Bioinformatics and computational biology not elsewhere classified
- Immunology not elsewhere classified
- Neurosciences not elsewhere classified
- Receptors and membrane biology
- Plant cell and molecular biology
- Animal cell and molecular biology
- Evolutionary biology not elsewhere classified
- Signal transduction
- Cancer cell biology
- Systems biology
- Structural biology (incl. macromolecular modelling)
Keywords
EmphysemaMMP (matrix metalloproteinases)Zbtb7c (Kr-pok)Cigarette smokingBiophysicsSynthetic BiologyBiochemistryPlant BiologyVirologyCell Development, Proliferation and DeathComputational BiologyImmunologyNeuroscienceReceptors and Membrane BiologyMolecular BiologyEvolutionary BiologySignal TransductionCancer Cell BiologySystems BiologyStructural Biology
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