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Dataset for: MicroRNA-661 modulates redox and metabolic homeostasis in Colon Cancer
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posted on 2017-10-11, 13:02 authored by Marta Gómez de Cedrón, Rebeca Acin, Ruth Sanchez-Martinez, Susana Molina, Jesús Herranz, Jaime Feliu, Guillermo Reglero, Jose-Antonio Enriquez, Ana Ramírez de MolinaCancer cell survival and metastasis are dependent on a metabolic reprogramming able to increase resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression. Herein we describe the role of microRNA-661 (miR661) as epigenetic regulator of colon cancer (CC) cell metabolism. miR661 induces a global increase in reactive oxygen species (ROS), specifically in mitochondrial superoxide anions (SO-), that seems to be mediated by decreased carbohydrate metabolism and pentose phosphate pathway, and by a higher dependency on mitochondrial respiration. miR661 overexpression in non-metastatic human CC cells induces an epithelial to mesenchymal transition (EMT) phenotype and a reduced tolerance to metabolic stress. This seems to be a general effect of miR661 in CC, since metastatic CC cells metabolism is also compromised upon miR661 overexpression. We propose hexose 6 phosphate dehydrogenase (H6PD) and pyruvate kinase M2 (PKM2) as two players related to the observed metabolic reprogramming. Finally, the clinical relevance of miR661 expression levels in stage-II and III CC patients is discussed. In conclusion, we propose miR661 as a potential modulator of redox and metabolic homeostasis in CC.
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- Oncology and carcinogenesis not elsewhere classified
- Tumour immunology
- Medical biochemistry and metabolomics not elsewhere classified
- Proteomics and intermolecular interactions (excl. medical proteomics)
- Plant cell and molecular biology
- Animal cell and molecular biology
- Clinical pharmacology and therapeutics
- Genomics
- Cancer cell biology
- Cancer genetics
- Chemotherapy
Keywords
miRoxidative stressmetabolomicsbioenergeticscolon cancerCancerTumour ImmunologyMedical Biochemistry and Metabolomics not elsewhere classifiedProteomics and Intermolecular Interactions (excl. Medical Proteomics)Molecular BiologyClinical Pharmacology and TherapeuticsBiomarkersGenomicsCancer Cell BiologyCancer GeneticsChemotherapy
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